Epstein-Barr Nuclear Antigen 1 modulates replication of oriP-plasmids by impeding replication and transcription fork migration through the family of repeats

Table 3 Copy number of replicated, Dpn I-resistant, plasmids detected 18 days after transfection into 293/EBNA1 cells.

Replication reporter transfected	Arrangement of EBNA1 binding sites	Plasmid copy number
AGP73	FR(10), DS	38 ± 11
AGP74	FR(20), DS	47 ± 8
AGP212	FR(10), DS, FR(10)	60 ± 11
AGP213	FR(10), FR(10), DS	51 ± 11
2380	wild-type oriP	44 ± 9

^a Numbers represent the average number of Dpn I-resistant episomal plasmid molecules per transfected cell detected in three experiments along with the standard deviation.

ISSN: 1743-422X