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Table 1 Nuclease resistance of REP 9, REP 9C and their non-phosphorothioated analogs

From: Amphipathic DNA polymers exhibit antiviral activity against systemic Murine Cytomegalovirus infection

    Nuclease resistance (- = fully degraded, ++++ = fully resistant)
compound sequence chemistry Phosphodiesterase II S1 Nuclease Bal 31 Exo I
REP 2015 N40 (degenerate) PO - - - -
REP 9   PS ++ - ++++ ++++
REP 2110 C40 PO ++++ ++ - -
REP 9C   PS ++++ ++ ++++ ++++
  1. PO = phosphodiester, PS = phosphorothioate