Identification of recombination break-point in Uruguayan H23 HCV strain. In (A) an alignment of 5'NCR plus core sequences of strains H23 and parental-like strains D11355 (sub-type 1b) and AF009606 (sub-type 1a) is shown. Identity to H23 is shown by a dash. Recombination break-point identified by GARD is shown by an arrow. In (B) a scheme representing H23 5'NCR plus core region sequences showing the recombination break-point is shown in the upper part of the figure. Numbers indicate nucleotide positions relative to strain AF009606. Maximum likelihood phylogenetic trees obtained using partial alignment before and after the recombination break-point are shown behind the scheme. Strains previously described are shown by their accession number and their genotype is indicated between parenthesis (see also Table 1). Strain H23 is shown by name and indicated by an arrow. Numbers at each branch of the trees show aLRT values. Bars at the bottom of the trees show distance.