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Figure 6 | Virology Journal

Figure 6

From: An HPV 16 L1-based chimeric human papilloma virus-like particles containing a string of epitopes produced in plants is able to elicit humoral and cytotoxic T-cell activity in mice

Figure 6

Immunization with VLPs and cVLPs induce cytotoxic specific T-lymphocytes in C57BL/6 mice. T lymphocytes derived from C57BL/6-immunized mice with Gardasil® (n = 6), VLPs (n = 3) or cVLPs (n = 6), as well as with the HPV 16 E749-57 (RAHYNIVTF, H-2Db-restricted) epitope (n = 6), were restimulated in vitro with the epitopes HPV 16 E749-57 (RAHYNIVTF, H-2Db-restricted) and HPV 16 L1 165–173 (AGVDNRECI, H-2Db-restricted) and their cytolytic activity was tested by a standard 4-h 51Cr release assay against TC-1 cells A and C; and on HPV 16 L1-transfected TC-1 cells (TC-1/L1) B and D. T:E, target effector cells ratio.

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Virology Journal

ISSN: 1743-422X