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Figure 6 | Virology Journal

Figure 6

From: Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions

Figure 6

Extracellular infectious viruses are decreased in the absence of UL56. Single-step growth analysis of 186 (wild-type), ΔUL56Z and ΔUL56Zrev viruses. Vero cells were infected with viruses at an MOI of 3 PFU/cell, and harvested at indicated times postinfection; culture medium and cells were analyzed together to determine 'whole' viral yields, or only culture medium were analyzed to determine 'extracellular' viral yields. (A) The results from one representative experiment are shown. (B) Results of extracellular viral yields from three independent experiments are shown as mean ± standard deviation. Extracellular ΔUL56Z showed statistically significant decreases compared to wild-type viruses. *p < 0.05, **p < 0.01; two-tailed t-test.

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Virology Journal

ISSN: 1743-422X