A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: Potential impact on CTL epitopes

Table 19 Effect of variant amino acids on CTL Epitope corresponding to residues 38–46 of Vpr

Amino Acid Sequence of Predicted Epitope	Score^β
Prototype sequence (start position 38)^α
WLHELGQQI	196.763
Natural variations observed at this epitope
CLHELGQQI	42.774
FLHELGQQI	196.763
TLHELGQQI	42.774
YLHELGQQI	196.763
WFHELGQQI	0.137
WLIELGQQI	196.763
WLLELGQQI	728.022
WLMELGQQI	728.022
WLNELGQQI	196.763
WLQELGQQI	196.763
WLRELGQQI	14.954
WLTELGQQI	196.763
WLYELGQQI	629.64
WLHALGQQI	47.991
WLHDLGQQI	196.763
WLHGLGQQI	47.991
WLHHLGQQI	47.991
WLHNLGQQI	47.991
WLHQLGQQI	47.991
WLHRLGQQI	47.991
WLHSLGQQI	47.991
WLHWLGQQI	47.991
WLHECGQQI	196.763
WLHEFGQQI	747.698
WLHEIGQQI	196.763
WLHEMGQQI	196.763
WLHEVGQQI	196.763
WLHELGEQI	96.414
WLHELGHQI	196.763
WLHELGKQI	196.763
WLHELGLQI	196.763
WLHELGNQI	196.763
WLHELGRQI	39.353
WLHELGTQI	196.763
WLHELGVQI	196.763
WLHELGQFI	1082.194
WLHELGQHI	196.763
WLHELGQLI	196.763
WLHELGQWI	1082.194
WLHELGQYI	1082.194
WLHELGQQD	0.281
WLHELGQQV	1311.751

^α Accession No.: A1.TZ.01.A341_AY253314
^β Estimate of Half Time of Disassociation of a Molecule Containing This Epitope

ISSN: 1743-422X