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Table 2 Titers of hMPV in hamsters after immunization and after challenge.

From: Deletion of human metapneumovirus M2-2 increases mutation frequency and attenuates growth in hamsters

Immunizing Virusa Mean virus titer post immunizationb (log10 PFU/gm tissue +/- SE) Mean virus titer post challengec (log10 PFU/gm tissue +/- SE)
  NT Lungs NT Lungs
wt hMPV/NL/1/00 5.9 +/- 0.3 4.6 +/- 1.4 <0.4 +/- 0.1 <0.4 +/- 0.1
rhMPV 6.0 +/- 0.6 5.1 +/- 0.5 <0.4 +/- 0.1 <0.4 +/- 0.1
rhMPV/ΔM2-2 2.3 +/- 0.6 3.3 +/- 0.4 <0.4 +/- 0.1 <0.4 +/- 0.1
placebo ND ND 5.6 +/- 0.6 4.5 +/- 1.5
  1. a Syrian golden hamsters, in groups of 8, were infected intranasally with 106 PFU/animal of the immunizing virus or placebo.
  2. b 4 animals per group were sacrificed on day 4 p.i.. Nasal turbinates and lungs were harvested and virus titers were determined by plaque assay.
  3. c 28 days posit immunization, 4 animals per group were challenged with 106 PFU/animal of wt hMPV/NL/1/00. 4 days post challenge, the animals were sacrificed. Nasal turbinates and lungs were harvested and virus titers were determined by plaque assay.