Immunizing Virusa | Mean virus titer post immunizationb (log10 PFU/gm tissue +/- SE) | Mean virus titer post challengec (log10 PFU/gm tissue +/- SE) | ||
---|---|---|---|---|
NT | Lungs | NT | Lungs | |
wt hMPV/NL/1/00 | 5.9 +/- 0.3 | 4.6 +/- 1.4 | <0.4 +/- 0.1 | <0.4 +/- 0.1 |
rhMPV | 6.0 +/- 0.6 | 5.1 +/- 0.5 | <0.4 +/- 0.1 | <0.4 +/- 0.1 |
rhMPV/ΔM2-2 | 2.3 +/- 0.6 | 3.3 +/- 0.4 | <0.4 +/- 0.1 | <0.4 +/- 0.1 |
placebo | ND | ND | 5.6 +/- 0.6 | 4.5 +/- 1.5 |