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Table 2 C-terminal PDZ sequences for different HPV types

From: Comparison of p53 and the PDZ domain containing protein MAGI-3 regulation by the E6 protein from high-risk human papillomaviruses

HPV Type (E6)

PDZ domain

18

L

Q

R

R

R

E

T

Q

V

45

L

R

R

R

R

E

T

Q

V

70

R

R

I

R

R

E

T

Q

V

58

R

P

R

R

R

Q

T

Q

V

16

S

R

T

R

R

E

T

Q

L

35

K

P

T

R

R

E

T

E

V

51

T

R

Q

R

N

E

T

Q

V

82

A

R

Q

R

S

E

T

Q

V

33

R

S

R

R

R

E

T

A

L

56

S

R

E

P

R

E

S

T

V

66

S

R

Q

A

T

E

S

T

V

53

H

T

T

A

T

E

S

A

V

  1. Comparison of the C-terminal PDZ-binding domains for E6 from high-risk HPV types relative to HPV-18 E6. Amino acid sequences homologous to HPV-18 are highlighted in boldy and amino acids matching the consensus PDZ-binding sequence X-T/S-X-V/L are underlined.