N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo

Table 1 List of Methylisatin-β-thiosemicarbazone (MIBT) derivatives and the CC₅₀ on PS and BHK-21 cells

*CC₅₀ = The concentration of the compound that reduced the viability of cells to 50% of the control. Note: The 14 MIBT compounds belonged to four different categories based on the halogen or methyl group substituted at the position R and are designated as SB group with bromine, SC group with chlorine, SF group with fluorine and SCH group with -CH3 group substituted at R. R' has N-substituted aromatic side chain attached to the -CH2 moiety. Cytotoxicity concentration (CC₅₀) of synthesized compounds was evaluated on exponentially growing PS and BHK-21 cells. It can be observed that the CC₅₀ of MIBT derivatives ranged from ≥ 76 ug/ml to ≥ 17 ug/ml, while CC₅₀ on BHK-21 cell line ranged from ≥ 200 ug/ml to ≥ 16.8 ug/ml.

ISSN: 1743-422X