Figure 5

Survival graphs depicting the in vivo effect of SCH 16 against a lethal JEV challenge. SCH 16 was administered to swiss albino mice (n = 4 per group) per orally twice daily at 12 hour intervals to three groups of mice. Each group of mice received the drug at 200 (red square), 400 (blue triangle) and 500 (black sphere) mg/kg body weight respectively. A forth group of mice (n = 4) served as virus control (green diamond) and did not receive the drug. All the groups of mice were challenged with 50LD₅₀JEV (P20778) by intraperitoneal route as described in materials and methods. The survival of mice was monitored for 20 days post-challenge. X-axis depicts the days post challenge. Y-axis depicts the percentage survival of mice treated with various concentrations of the drug as wells untreated control mice. Each data point depicts the mean survival rate of four mice in the respective group. Note that all mice in the virus control group succumbed by 7 days post challenge.