Table 1 Chemokines encoded by human viruses and their human and murine chemokine receptor targets.
Virus | Gene | Protein | human chemokine receptor targets | Ref | also targeting the corresponding murine chemokine receptor | Ref |
|---|---|---|---|---|---|---|
CMV | UL146 | vCXCL1 | Selective CXCR2 agonist | 11 | No | 20 |
UL147 | vCXCL2 | ? | ||||
HHV6 a | U83B | vCCL4 | Selective CCR2 agonist | 9 | ? | |
HHV8 | K6 | vCCL1 (vMIP-I) | Selective CCR8 agonist | 3,5,10 | Yes | 18 |
K4 | vCCL2 (vMIP-II) | Broadspectrum chemokine receptor | ||||
antagonist | ||||||
CCR1 | 6,7 | Yes | 19 | |||
CCR2 | 6,7 | Yes | 19 | |||
CCR5 | 6,7 | Yes | 19 | |||
XCR1 | 7 | No | This paper | |||
CX3CR1 | 7 | ? | ||||
CXCR4 | 6,7 | ? | ||||
CCR3 agonist | 17 | ? | ||||
K4.1 | vCCL3 (vMIP-III) | Selective XCR1 agonist | 10 | No | This paper | |
MCV | MC148 | MCC | Selective CCR8 antagonist | 7 | No | 18 |