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Table 3 Infection of rhesus monkeys with LACV results in limited changes in blood chemistries or cell counts.

From: La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys

   

Mean test value on indicated day post inoculationa

Testb

Unit

Mean ± SDc

2

4

6

8

10

12

14

21

28

CBC

           

White blood count

THSN/UL

9.7 ± 2.9

7.9

9.2

9.2

8.3

8.2

8.5

8.0

6.7

7.2

Red blood count

MILL/UL

5.7 ± 0.3

5.5

5.4

5.3

4.8

5.0

5.2

5.2

5.4

5.1

Hemoglobin

GM/DL

12.8 ± 0.5

12.7

12.3

11.9

11.0

11.5

11.6

11.4

12.1

11.8

Hematocrit

Percent

38.9 ± 1.7

38.7

37.7

36.8

33.8

35.8

35.8

35.8

38.2

37.1

MCV

FL

68.5 ± 2.7

71

70.4

68.9

68.1

71.1

68.6

69.9

70.2

72.2

MCH

PICO GM

22.5 ± 0.8

23.3

23.0

22.4

22.4

22.8

22.2

22.0

22.2

23.0

MCHC

Percent

32.9 ± 0.8

32.9

32.7

32.5

32.7

32.0

32.4

31.4

31.7

31.9

Platelet

THSN/UL

391.7 ± 83.6

419.4

371.3

348.2

395.3

449.9

432.2

431.4

445.2

389.5

Differential

           

Absolute polys

THSN/UL

3550.7 ± 1779.4

2057.5

4299.9

3888.3

4243.2

3539.1

3649.1

2758.6

2291.6

2510.0

Bands

THSN/UL

0 ± 0

0

0

0

0

0

0

0

0

0

Lymphocytes

THSN/UL

5301.9 ± 1830.4

5142.9

4347.6

4773.3

3727.5

4054.3

4300.8

4187.0

3817.5

3803.4

Monocytes

THSN/UL

342.9 ± 148.0

362.1

351.6

365.4

297.1

341.0

277.2

272.0

253.8

241.5

Eosinophils

THSN/UL

257.6 ± 181.1

209.8

200.8

230.0

167.9

290.6

235.9

213.7

229.6

180.8

Basophiles

THSN/UL

0 ± 0

0

0

0

8.1

0

0

0

13.8

0

Chemistry

           

Sodium

MEQ/L

152.2 ± 3.5

152.2

152.2

152.2

152.2

152.2

152.2

152.2

152.2

152.2

Potassium

MEQ/L

3.9 ± 0.5

4.2

3.9

3.8

3.6

4.1

3.8

4.1

4.2

3.8

Chloride

MEQ/L

110.6 ± 3.5

110.6

110.2

109.1

108.1

110.4

105.0

107.1

110.3

106.7

Calcium total

MG/DL

9.7 ± 0.3

9.5

9.5

9.3

9.0

9.4

9.6

9.4

9.6

9.8

Phosphorus

MG/DL

5.9 ± 1.0

5.9

5.8

5.4

5.6

5.9

5.8

5.6

5.8

6.7

Magnesium

MEQ/L

1.7 ± 0.2

1.8

1.7

1.6

1.7

1.8

1.6

1.6

1.6

1.8

AST (SGOT)

U/L

38.5 ± 7.4

39.1

43.7

46.8

41.3

43.2

48.4

39.6

36.4

55.0

ALT (SGPT)

U/L

29.4 ± 9.5

31.2

34.1

35.9

36.4

34.8

34.8

33.0

26.5

30.9

ALP

U/L

692.0 ± 166.2

604.5

586.1

597.0

597.8

510.1

532.6

548.5

529.4

553.5

Amylase

U/L

203.0 ± 56.0

231.5

219.3

211.1

203.2

221.8

228.8

216.5

206.3

215.6

Glucose

MG/DL

65.0 ± 11.3

76.9

88.6

116.7

132.8

70.4

66.8

65.4

64.8

66.8

BUN

MG/DL

20.0 ± 7.5

18.5

19.2

16.6

18.1

22.9

18.9

18.7

16.3

22.0

Creatinine

MG/DL

0.8 ± 0.2

0.7

0.8

0.7

0.8

0.7

0.7

1.2

0.8

0.8

Cholesterol

MG/DL

153.8 ± 31.4

157.1

153.6

139.8

142.3

158.6

150.3

148.6

146.3

151.6

Triglyceride

MG/DL

65.3 ± 21.7

47.1

59.9

75.4

49.5

37.7

61.1

70.5

58.7

60.8

Bilirubin, total

MG/DL

0.2 ± 0.1

0.2

0.2

0.2

0.2

0.2

0.2

0.2

0.1

0.2

Albumin

G/DL

4.5 ± 0.2

4.5

4.5

4.2

4.2

4.4

4.3

4.2

4.3

4.6

Protein, total

G/DL

6.9 ± 0.3

6.9

6.9

6.5

6.5

6.9

6.6

6.6

6.8

7.2

Globulin

G/DL

2.4 ± 0.2

2.4

2.4

2.3

2.4

2.5

2.4

2.4

2.6

2.6

Lipase-PS

U/L

32.4 ± 27.6

30.4

27.7

53.1

25.4

32.2

38.4

39.5

33.1

28.7

Osmolality, Calculated

mOsm/kg

306.0 ± 55.1

298.1

300.1

299.6

292.6

297.1

286.8

288.1

296.3

288.9

  1. aDays with significant number of monkeys 1 SD from the pre-inoculation mean (day -7 and 0 combined) are boxed (chi square, p < 0.05, n = 16), mean values displayed.
  2. bAbbreviations: MCV-mean corpuscular volume, MCH-mean corpuscular hemoglobin, MCHC-mean corpuscular hemoglobin concentrations, AST-aspartate aminotransferase, ALT-alanine aminotransferase, ALP-alkaline phosphatase, BUN-blood urea nitrogen.
  3. cPre-inoculation mean determined from samples collected on days -7 and 0 post inoculation.
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