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Table 3 Infection of rhesus monkeys with LACV results in limited changes in blood chemistries or cell counts.

From: La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys

    Mean test value on indicated day post inoculationa
Testb Unit Mean ± SDc 2 4 6 8 10 12 14 21 28
CBC            
White blood count THSN/UL 9.7 ± 2.9 7.9 9.2 9.2 8.3 8.2 8.5 8.0 6.7 7.2
Red blood count MILL/UL 5.7 ± 0.3 5.5 5.4 5.3 4.8 5.0 5.2 5.2 5.4 5.1
Hemoglobin GM/DL 12.8 ± 0.5 12.7 12.3 11.9 11.0 11.5 11.6 11.4 12.1 11.8
Hematocrit Percent 38.9 ± 1.7 38.7 37.7 36.8 33.8 35.8 35.8 35.8 38.2 37.1
MCV FL 68.5 ± 2.7 71 70.4 68.9 68.1 71.1 68.6 69.9 70.2 72.2
MCH PICO GM 22.5 ± 0.8 23.3 23.0 22.4 22.4 22.8 22.2 22.0 22.2 23.0
MCHC Percent 32.9 ± 0.8 32.9 32.7 32.5 32.7 32.0 32.4 31.4 31.7 31.9
Platelet THSN/UL 391.7 ± 83.6 419.4 371.3 348.2 395.3 449.9 432.2 431.4 445.2 389.5
Differential            
Absolute polys THSN/UL 3550.7 ± 1779.4 2057.5 4299.9 3888.3 4243.2 3539.1 3649.1 2758.6 2291.6 2510.0
Bands THSN/UL 0 ± 0 0 0 0 0 0 0 0 0 0
Lymphocytes THSN/UL 5301.9 ± 1830.4 5142.9 4347.6 4773.3 3727.5 4054.3 4300.8 4187.0 3817.5 3803.4
Monocytes THSN/UL 342.9 ± 148.0 362.1 351.6 365.4 297.1 341.0 277.2 272.0 253.8 241.5
Eosinophils THSN/UL 257.6 ± 181.1 209.8 200.8 230.0 167.9 290.6 235.9 213.7 229.6 180.8
Basophiles THSN/UL 0 ± 0 0 0 0 8.1 0 0 0 13.8 0
Chemistry            
Sodium MEQ/L 152.2 ± 3.5 152.2 152.2 152.2 152.2 152.2 152.2 152.2 152.2 152.2
Potassium MEQ/L 3.9 ± 0.5 4.2 3.9 3.8 3.6 4.1 3.8 4.1 4.2 3.8
Chloride MEQ/L 110.6 ± 3.5 110.6 110.2 109.1 108.1 110.4 105.0 107.1 110.3 106.7
Calcium total MG/DL 9.7 ± 0.3 9.5 9.5 9.3 9.0 9.4 9.6 9.4 9.6 9.8
Phosphorus MG/DL 5.9 ± 1.0 5.9 5.8 5.4 5.6 5.9 5.8 5.6 5.8 6.7
Magnesium MEQ/L 1.7 ± 0.2 1.8 1.7 1.6 1.7 1.8 1.6 1.6 1.6 1.8
AST (SGOT) U/L 38.5 ± 7.4 39.1 43.7 46.8 41.3 43.2 48.4 39.6 36.4 55.0
ALT (SGPT) U/L 29.4 ± 9.5 31.2 34.1 35.9 36.4 34.8 34.8 33.0 26.5 30.9
ALP U/L 692.0 ± 166.2 604.5 586.1 597.0 597.8 510.1 532.6 548.5 529.4 553.5
Amylase U/L 203.0 ± 56.0 231.5 219.3 211.1 203.2 221.8 228.8 216.5 206.3 215.6
Glucose MG/DL 65.0 ± 11.3 76.9 88.6 116.7 132.8 70.4 66.8 65.4 64.8 66.8
BUN MG/DL 20.0 ± 7.5 18.5 19.2 16.6 18.1 22.9 18.9 18.7 16.3 22.0
Creatinine MG/DL 0.8 ± 0.2 0.7 0.8 0.7 0.8 0.7 0.7 1.2 0.8 0.8
Cholesterol MG/DL 153.8 ± 31.4 157.1 153.6 139.8 142.3 158.6 150.3 148.6 146.3 151.6
Triglyceride MG/DL 65.3 ± 21.7 47.1 59.9 75.4 49.5 37.7 61.1 70.5 58.7 60.8
Bilirubin, total MG/DL 0.2 ± 0.1 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.1 0.2
Albumin G/DL 4.5 ± 0.2 4.5 4.5 4.2 4.2 4.4 4.3 4.2 4.3 4.6
Protein, total G/DL 6.9 ± 0.3 6.9 6.9 6.5 6.5 6.9 6.6 6.6 6.8 7.2
Globulin G/DL 2.4 ± 0.2 2.4 2.4 2.3 2.4 2.5 2.4 2.4 2.6 2.6
Lipase-PS U/L 32.4 ± 27.6 30.4 27.7 53.1 25.4 32.2 38.4 39.5 33.1 28.7
Osmolality, Calculated mOsm/kg 306.0 ± 55.1 298.1 300.1 299.6 292.6 297.1 286.8 288.1 296.3 288.9
  1. aDays with significant number of monkeys 1 SD from the pre-inoculation mean (day -7 and 0 combined) are boxed (chi square, p < 0.05, n = 16), mean values displayed.
  2. bAbbreviations: MCV-mean corpuscular volume, MCH-mean corpuscular hemoglobin, MCHC-mean corpuscular hemoglobin concentrations, AST-aspartate aminotransferase, ALT-alanine aminotransferase, ALP-alkaline phosphatase, BUN-blood urea nitrogen.
  3. cPre-inoculation mean determined from samples collected on days -7 and 0 post inoculation.