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Table 1 Spread of virus from brain to spinal cord after IP inoculation with 104.5 PFU LACV/human/1960.

From: La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys

  No. of mice with detectable viral antigen or histopathologic lesionsa
  Brain Spinal cord
  Olfactory bulb Thalamus Cerebral cortex Medulla Cerebellum Cervical Thoracic Lumbar
Day IHCb HEc IHC HE IHC HE IHC HE IHC HE IHC HE IHC HE IHC HE
1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
4 1 1 1 1 1 0 1 1 0 0 0 0 0 0 0 0
5 3 0 3 1 2 0 1 0 1 0 1 1 1 1 1 1
6 3 2 3 3 3 2 3 2 1 0 2 2 2 1 1 0
  1. a Data displayed as total positive by IHC and HE (n = 3). Viral antigen or lesions were not observed in nasal turbinates, muscle, spleen, or pancreas. Tissues from three control mice were collected on days 1 and 6 and processed for HE and IHC comparisons, viral antigen or lesions were not present.
  2. b Immunohistochemical stain
  3. c Hemotoxylin and eosin stain