Figure 5From: Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expressionModel for the role of p38 MAPK in adenovirus infected keratocytes. Upon infection, p38 MAPK is phosphorylated in a Src-dependent fashion. p38 MAPK then phosphorylates IκB resulting in NFκB-p65 activation. Activated NFκB-p65 translocates to the nucleus where it binds specifically to the IL-8 promoter to transactivate IL-8 gene expression.Back to article page