Figure 1
From: Complete genome sequence of a highly divergent astrovirus isolated from a child with acute diarrhea
Multiple sequence alignments of putative astrovirus regulatory regions. A.) Alignment of the 20 nucleotides at the very 5' end of the Astrovirus MLB1 genome with those of fully sequenced astroviruses. MLB1 only shares 13 of the 20 conserved nucleotides present in human strains 1–8. B.) Alignment of the 52 nt highly conserved nucleotide motif (shown in box) present immediately upstream of the ORF1b/ORF2 junction of Astrovirus MLB1 and other astroviruses. (Note: there is no overlap in the Turkey Astroviruses). MLB1 lacks the high degree of sequence identity seen between the human astroviruses. The start codon of ORF2 is shown underlined and the stop codon of ORF1b is shown italicized in bold for each virus.