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Table 5 HPV status of the placental and delivery factors.

From: Transplacental transmission of Human Papillomavirus

Maternal variable Placental HPV DNA infection
  Positive (n = 12) Negative (n = 37)
Type of HPV lesion     
Genital warts 5 (41.7%) 23 (62.2%)
LGSIL1 3 (25%) 9 (24.3%)
HGSIL2 4 (33.3%) 5 (13.5%)
Site of HPV lesion     
Uterine cervix 8 (66.7%) 13 (35.1%)
Vulva 3 (25%) 13 (35.1%)
Vulva + vagina - - 7 (18.9%)
Vulva + perineal region - - 1 (2.7%)
Uterine cervix + vulva + vagina 1 (8.3%) 3 (8.1%)
Type of HPV Infection     
Single 3 (25%) 16 (43.2%)
Double 2 (16.7%) 13 (35.1%)
Multiple 7 (58.3%) 8 (21.6%)
Type of delivery     
Vaginal 8 (66.7%) 15 (40.5%)
Vaginal + forceps - - 1 (2.7%)
Cesarean section 4 (33.3%) 21 (56.8%)
Mean gestational age of the delivery in the placental HPV DNA positive group (39.7 ± 1.1 weeks)     
Mean gestational age of the delivery in the placental HPV DNA negative group (39.2 ± 2.4 weeks)     
Gestational age at the time HPV infection was diagnosed (week)     
≥ 4 to ≤ 12 2 (16.7%) 17 (45.9%)
≥ 13 to ≤ 28 4 (33.3%) 8 (21.6%)
≥ 29 to ≤ 42 1 (8.3%) 6 (18.9%)
Prior to pregnancy 5 (41.7%) 5 (13.5%)
Mean in the placental HPV DNA positive group (10.5 ± 13.3 weeks)     
Mean in the placental HPV DNA negative group (14.63 ± 12 weeks)     
Time of RUPREME 3 (min)     
≤ 360 11 (100%) 35 (92.1%)
≥ 361 to ≤ 720 - - 1 (2.6%)
≥ 721 - - 2 (5.3%)
Mean of placental HPV DNA positive group (37 ± 37 minutes) - - - -
Mean of placental HPV DNA negative group (106 ± 244 minutes) - - - -
Duration of labor (min)     
≤ 240 6 (54.5%) 22 (57.9%)
≥ 241 to ≤ 360 2 (18.2%) 10 (26.3%)
≥ 361 3 (27.3%) 6 (15.8%)
Mean of placental HPV DNA positive group (236 ± 196 minutes) - - - -
Mean of placental HPV DNA negative group (185 ± 203 minutes) - - - -
HPV lesion at delivery     
Yes 7 (58.3%) 19 (51.4%)
No 5 (41.7%) 18 (48.6%)
  1. Data are reported as number and percentage (in parentheses) of infection placental positive or negative for human papillomavirus. *P < 0.05 indicates a statistically significant difference between the positive and negative groups by Pearson's chi-square test. 1Low-grade squamous intraepithelial lesions. 2High-grade squamous intraepithelial lesions. 3RUPREME = rupture of membrane amniotic.