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Table 5 HPV status of the placental and delivery factors.

From: Transplacental transmission of Human Papillomavirus

Maternal variable

Placental HPV DNA infection

 

Positive (n = 12)

Negative (n = 37)

Type of HPV lesion

    

Genital warts

5

(41.7%)

23

(62.2%)

LGSIL1

3

(25%)

9

(24.3%)

HGSIL2

4

(33.3%)

5

(13.5%)

Site of HPV lesion

    

Uterine cervix

8

(66.7%)

13

(35.1%)

Vulva

3

(25%)

13

(35.1%)

Vulva + vagina

-

-

7

(18.9%)

Vulva + perineal region

-

-

1

(2.7%)

Uterine cervix + vulva + vagina

1

(8.3%)

3

(8.1%)

Type of HPV Infection

    

Single

3

(25%)

16

(43.2%)

Double

2

(16.7%)

13

(35.1%)

Multiple

7

(58.3%)

8

(21.6%)

Type of delivery

    

Vaginal

8

(66.7%)

15

(40.5%)

Vaginal + forceps

-

-

1

(2.7%)

Cesarean section

4

(33.3%)

21

(56.8%)

Mean gestational age of the delivery in the placental HPV DNA positive group (39.7 ± 1.1 weeks)

    

Mean gestational age of the delivery in the placental HPV DNA negative group (39.2 ± 2.4 weeks)

    

Gestational age at the time HPV infection was diagnosed (week)

    

≥ 4 to ≤ 12

2

(16.7%)

17

(45.9%)

≥ 13 to ≤ 28

4

(33.3%)

8

(21.6%)

≥ 29 to ≤ 42

1

(8.3%)

6

(18.9%)

Prior to pregnancy

5

(41.7%)

5

(13.5%)

Mean in the placental HPV DNA positive group (10.5 ± 13.3 weeks)

    

Mean in the placental HPV DNA negative group (14.63 ± 12 weeks)

    

Time of RUPREME 3 (min)

    

≤ 360

11

(100%)

35

(92.1%)

≥ 361 to ≤ 720

-

-

1

(2.6%)

≥ 721

-

-

2

(5.3%)

Mean of placental HPV DNA positive group (37 ± 37 minutes)

-

-

-

-

Mean of placental HPV DNA negative group (106 ± 244 minutes)

-

-

-

-

Duration of labor (min)

    

≤ 240

6

(54.5%)

22

(57.9%)

≥ 241 to ≤ 360

2

(18.2%)

10

(26.3%)

≥ 361

3

(27.3%)

6

(15.8%)

Mean of placental HPV DNA positive group (236 ± 196 minutes)

-

-

-

-

Mean of placental HPV DNA negative group (185 ± 203 minutes)

-

-

-

-

HPV lesion at delivery

    

Yes

7

(58.3%)

19

(51.4%)

No

5

(41.7%)

18

(48.6%)

  1. Data are reported as number and percentage (in parentheses) of infection placental positive or negative for human papillomavirus. *P < 0.05 indicates a statistically significant difference between the positive and negative groups by Pearson's chi-square test. 1Low-grade squamous intraepithelial lesions. 2High-grade squamous intraepithelial lesions. 3RUPREME = rupture of membrane amniotic.