Figure 2

Quasispecies complexity within E1/E2 region in the unfractionated serum, the IgG-depleted fraction and the IgG-enriched fraction:(A) at the nucleotide level and (B) at the amino acid level. The vertical bars indicate the proportion of viral variants within each sample. Within the vertical bars, each variant is represented by a different colour. The same colour indicates identity between viral strains present in different fractions. The accession numbers and corresponding viral variant colour code of each strain are shown in the legend box where font colour corresponds to each fraction as follows: red for the unfractionated serum, blue for the IgG-depleted fraction, green for the IgG-enriched fraction [EU482135] was also the subdominant species of the unfractionated fraction), and black for quasispecies present in both unfractionated and IgG-depleted fractions. An accession number followed by an asterisk (*) indicates the presence of an insertion event within the sequence or 2 asterisks (**) indicates the presence of an indel event.