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Figure 2 | Virology Journal

Figure 2

From: Discovery of herpesviruses in multi-infected primates using locked nucleic acids (LNA) and a bigenic PCR approach

Figure 2

Alignment of LNA-substituted oligonucleotides. The LNAs, used in this study for specific inhibition of LCV amplification, were multiply aligned with their target sequences. The LNA-substituted bases are highlighted by circles. Identical nucleotides are boxed. For comparison, an LCV consensus sequence is shown, which was derived from all published LCV DPOL sequences. The bases 1 and 175 are the first and the last base of the sequence, which is amplified from LCV with pan-herpes DPOL primers (Bases 154668 and 154494 of the EBV B 95–8 genome [Acc. V01555], respectively). Only the 5'- and the 3'-ends are shown, the central part of the consensus sequence is represented by the dotted line. The 3'- ends of the binding regions of the inner consensus primers TGV (sense) and IYG (antisense) are indicated.

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Virology Journal

ISSN: 1743-422X