Figure 6From: Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modificationProposed model of HSV-1 ICP4 and ICP22 regulation by REST/NRSF. REST/NRSF interacts with HSV-1 RE-1 in chromatin and represses ICP4 by recruiting CoREST and HDAC to induce hypoacetylation around the ICP4 promoter.Back to article page