Figure 7
Postulated mechanism of ribavirin action under RH. Translation of normal viral quasispecies RNAs (panel A) result in normal Envwt: Envmt concentrations of distribution and normal Env:RNApol interactions resulting in normal rapid low-fidelity replication. Incorporation of ribavirin (â—†, panel B) into viral RNAs and subsequent translation of excess mutated Envmt viral proteins, causing abnormal relative Envwt: Envmt concentrations and Env:RNApol interactions dominated by Envmt:RNApol interactions that cause increased RNApol fidelity and reduced processivity.