Different rates of (non-)synonymous mutations in astrovirus genes; correlation with gene function

Table 1 Values for (non-)synonymous mutational rates and dN/dS ratios in astrovirus genes

Species		ORF1a			ORF1b			ORF2
TipBranche	AccNum	dN	dS	dN/dS	dN	dS	dN/dS	dN	dS	dN/dS
Human1	Z25771	0.0040	0.0445	0.0899	0.0026	0.0775	0.0335	0.0049	0.0503	0.0974
Human1	L23513	0.0031	0.0228	0.1360	0.0000	0.0130	0.0000	0.0057	0.0386	0.1477
Human2	L13745	0.0047	0.0514	0.0914	0.0086	0.1326	0.0649	0.1334	0.8681	0.1537
Human3	AF141381	0.0085	0.2177	0.0390	0.0143	0.3686	0.0388	0.0415	0.5710	0.0727
Human4	DQ070852	0.0068	0.2338	0.0291	0.0033	0.1517	0.0218	0.1564	0.5992	0.2610
Human5	DQ028633	0.0122	0.1390	0.0878	0.0061	0.1872	0.0326	0.0959	0.7401	0.1296
Human6	Z46658							0.0876	0.7478	0.1171
Human7	Y08632							0.0582	0.5862	0.0993
Human8	AF260508	0.0075	0.1508	0.0497	0.0033	0.1802	0.0183	0.0536	0.4412	0.1215
Sheep	Y15937	0.3386	28.9094	0.0117	0.1369	8.2335	0.0166	0.2367	46.6085	0.0051
Mink	AY179509	0.2348	24.9745	0.0094	0.1357	32.7666	0.0041	0.2994	28.4143	0.0105
Cat	AF056197							0.1262	0.6628	0.1904
Pig	AB037272							0.2204	28.9632	0.0076
Turkey1	Y15936	0.3483	37.4061	0.0093	0.2029	18.8746	0.0107	0.1717	30.1582	0.0057
Turkey2	AF206663	0.2821	11.8241	0.0239	0.1604	11.5272	0.0139	0.3652	20.9202	0.0175
ANV	AB033998	0.3863	25.2068	0.0153	0.1692	41.9092	0.0040	0.1007	1.3416	0.0751
ANV2	AB046864	0.1208	1.0567	0.1143

The virus isolates available for analysis of ORF1a, ORF1b and ORF2 are mentioned in the first column and specified by their accession numbers. With respect to ORF2, one representative per human serotype was included. Separate values for dN and dS of the species' tip branches as well as their ratios are presented for each ORF, individually. Values for dN/dS exceeding 0.15 are in italics. Ancestral branches were not included.

ISSN: 1743-422X