Figure 7
From: Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses
Thymus atrophy in mice infected with WR and Wyeth strains. (A) Pictures of the thymus in mice infected intranasally with 106 p.f.u. or 104 p.f.u. of WR or 106 p.f.u. of Wyeth at 5 days post-infection. Arrows indicate the thymi. (B) The numbers of thymocytes from mice infected with WR and Wyeth strains at 3 (white bar), 5 (light gray bar), 10 (dark gray bar) and 18 (black bar) days post-infection. Thymocyets were pooled from groups of three mice and counted. Data are shown as the average numbers of thymocytes per mouse. The dotted line is the average number of thymocytes from uninfected mice. ND; not determined. (C) Virus titers in thymus of mice infected with WR and Wyeth strains at 3 (white bar), 5 (light gray bar), and 10 (dark gray bar) days post-infection. Titers are shown as p.f.u. per organ in log scale. The error bars indicate the standard deviations in triplicate samples. The dotted line indicates the detection limit. ND; not determined. (D) CD4 and CD8 expressions of thymocyets from mice infected with WR and Wyeth strains at 5 (upper five panels) and 10 (lower two panels) days post-infection.