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Figure 5 | Virology Journal

Figure 5

From: The effects of DNA methylation and histone deacetylase inhibitors on human papillomavirus early gene expression in cervical cancer, an in vitro and clinical study

Figure 5

p53 acetylation. 5a. Immunoprecipitation assays showing that the three drugs or the combination hyperacetylated p53 at lysine 373 whereas only the combination of hydralazine-valproate did at lysine 382 in CaLo cells. Lysine 373 was hyperacetylated in Caski by the combination. 5b. Interaction by immunoprecipitation with E6 antibody and then Western blotted with a p53 antibody showing an increased p53 indicating that acetylation of p53 protects its degradation by E6. 5c. Transactivation effect o p53 upon bax protein. Hydralazine and valproate in combination led to a strong increase in bax protein.

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Virology Journal

ISSN: 1743-422X