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Table 3 Viral load, and quasispesies variability in different study groups

From: Genetic distance and heterogenecity between quasispecies is a critical predictor to IFN response in Egyptian patients with HCV genotype-4

Factor

Responders (n = 13)

#Non-responders (n = 6)

untreated controls (n = 8)

P value*

Base line viral load:

**(mean ± SD)

661.8 ± 1286.7

391.3 ± 201.4

329.4 ± 183.1

0.719

No of quasispecies:

Median (range)

2.0 (1–32)

2.0 (1–8)

1.0 (1–4)

0.262

Sequence diversity***:

    

Insertions:

1.08 ± 1.9

0.33 ± 0.52

1.5 ± 1.7

0.345

Deletions :

1.2 ± 0.59

0.66 ± 0.82

1.1 ± 0.83

0.304

Transitions:

1.8 ± 0.9

4.7 ± 2.0

7.0 ± 6.8

0.007*

Tnasversions:

2.0 ± 2.5

2.5 ± 2.1

4.3 ± 4.5

0.482

Transition/Transversion:

1.3 ± 1.1

2.4 ± 1.2

2.3 ± 3.2

0.183

No. of mutation spots

6.2 ± 3.1

8.2 ± 4.2

13.9 ± 11.1

0.275

Genetic distance

0.005 ± 0.24

0.14 ± 0.73

0.19 ± 0.48

0.035*

  1. # Non-responders include I non responder and 6 viral breakthrough patients, * P value is significant between responder and non-responders, **Viral load in thousands *** (mean ± SD)
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Virology Journal

ISSN: 1743-422X