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Table 2 Prediction of coreceptor usage by Position Specific Scoring Matrix (PSSM) bioinformatics tool that predicts coreceptor usage.

From: Role of HIV-1 subtype C envelope V3 to V5 regions in viral entry, coreceptor utilization and replication efficiency in primary T-lymphocytes and monocyte-derived macrophages

Patient/Clone

Software

Score

Pred

X4 pct

R5 pct

Geno

Pos chg

Net Chg

Percent

AP.17/171, 173

X4/R5

-3.58

0

0.47

0.98

SE

6

4

0.83

 

Sinsi

-7.05

0

0.04

0.90

SE

6

4

0.83

AP.18/182, 183

X4/R5

-6.48

0

0.27

0.95

SD

6

4

0.70

 

Sinsi

-10.73

0

0.04

0.58

SD

6

4

0.70

AP.2/221A

X4/R5

-7.83

0

0.22

0.9

SD

7

5

0.57

 

Sinsi

-9.5

0

0.04

0.73

SD

7

5

0.57

AP.28/282, 284

X4/R5

-8.89

0

0.22

0.88

SE

7

5

0.44

 

Sinsi

-12.12

0

0.01

0.2

SE

7

5

0.44

AP.33/331, 334

X4/R5

-7.36

0

0.24

0.92

SE

6

4

0.62

 

Sinsi

-10.61

0

0.04

0.51

SE

6

4

0.62

AP.4/452, 454

X4/R5

-6.50

0

0.27

0.95

SD

5

2

0.67

 

Sinsi

-11.53

0

0.01

0.32

SD

5

2

0.67

AP.5/512, 514

X4/R5

-9.74

0

0.22

0.82

SE

5

3

0.33

 

Sinsi

-10.69

0

0.01

0.50

SE

5

3

0.33

AP.6/639

X4/R5

-9.06

0

0.22

0.86

SD

6

4

0.48

 

Sinsi

-12.26

0

0.01

0.17

SD

6

4

0.48

AP.10/1011, 1014

X4/R5

-9.36

0

0.22

0.83

SE

6

4

0.31

 

Sinsi

-11.16

0

0.01

0.04

SE

6

4

0.31