|
Immunogen
|
Animals (n)
|
PRNT50*
|
ELISA-EGFP***
|
| | |
% Sero-conversion
|
GMT ± SD
|
Titer Range**
|
% Sero-conversion
|
GMT ± SD
|
Titer Range
|
|
YF 17DD
|
15
|
100
|
140 ± 80
|
45 – 308
|
0
|
< 16
|
< 16
|
|
YF17D/Esa/5.1glic
|
20
|
100
|
80 ± 47
|
37 – 211
|
80
|
158 ± 1,144
|
26 – 3,535
|
|
199 Earle's Medium
|
15
|
0
|
< 10
|
< 10
|
0
|
< 16
|
< 16
|
- * Reciprocal of the dilution yielding 50% plaque reduction.
- ** Differences in the titers of neutralizing antibodies virus in animals immunized with YF 17DD and YF17D/Esa/5.1glic were statistically significant (t test; P < 0.02).
- ***The titer of antibodies directed against EGFP was calculated based on standard curves of a monoclonal antibody specific to GFP and is expressed in ng/mL.
