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Table 1 Immunogenicity of YF17D/Esa/5.1glic for BALB/c mice.

From: Construction and characterization of recombinant flaviviruses bearing insertions between E and NS1 genes

Immunogen Animals (n) PRNT50* ELISA-EGFP***
   % Sero-conversion GMT ± SD Titer Range** % Sero-conversion GMT ± SD Titer Range
YF 17DD 15 100 140 ± 80 45 – 308 0 < 16 < 16
YF17D/Esa/5.1glic 20 100 80 ± 47 37 – 211 80 158 ± 1,144 26 – 3,535
199 Earle's Medium 15 0 < 10 < 10 0 < 16 < 16
  1. * Reciprocal of the dilution yielding 50% plaque reduction.
  2. ** Differences in the titers of neutralizing antibodies virus in animals immunized with YF 17DD and YF17D/Esa/5.1glic were statistically significant (t test; P < 0.02).
  3. ***The titer of antibodies directed against EGFP was calculated based on standard curves of a monoclonal antibody specific to GFP and is expressed in ng/mL.