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Table 1 Immunogenicity of YF17D/Esa/5.1glic for BALB/c mice.

From: Construction and characterization of recombinant flaviviruses bearing insertions between E and NS1 genes

Immunogen

Animals (n)

PRNT50*

ELISA-EGFP***

  

% Sero-conversion

GMT ± SD

Titer Range**

% Sero-conversion

GMT ± SD

Titer Range

YF 17DD

15

100

140 ± 80

45 – 308

0

< 16

< 16

YF17D/Esa/5.1glic

20

100

80 ± 47

37 – 211

80

158 ± 1,144

26 – 3,535

199 Earle's Medium

15

0

< 10

< 10

0

< 16

< 16

  1. * Reciprocal of the dilution yielding 50% plaque reduction.
  2. ** Differences in the titers of neutralizing antibodies virus in animals immunized with YF 17DD and YF17D/Esa/5.1glic were statistically significant (t test; P < 0.02).
  3. ***The titer of antibodies directed against EGFP was calculated based on standard curves of a monoclonal antibody specific to GFP and is expressed in ng/mL.
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Virology Journal

ISSN: 1743-422X