Figure 9
From: Development of a model for marburgvirus based on severe-combined immunodeficiency mice
Use of the 'scid-adapted' MARV model to assess the efficacy of potential therapeutics for MARV. Scid mice were infected IP with ~1000 pfu of 'scid-adapted' MARV-Ci67. At 1 h postchallenge, groups of scid mice (n = 10) were treated IP with 1 ml of convalescent serum from guinea pigs that had survived MARV or EBOV challenge. Alternately, groups of mice were treated with 1 mg each of VP24, VP35, NP and L PMOs or saline alone as a vehicle control. The mice were monitored for >70 days for survival and the data are presented on a Meier-Kaplan curve as percent survival for each group.