Figure 1

Global gene expression analysis of liver tissue from HCV and ethanol-associated cirrhosis. 2-D hierarchical clustering was performed using Resolver System software with agglomerative algorithm, average link heuristic criteria, and Euclidian correlation metric. Each column represents gene expression data from an individual experiment comparing cirrhotic and normal liver and the cluster represents 2965 genes that showed a >2-fold change (P value < 0.05) in at least 3 of 15 experiments. A full view is shown with green and red colors showing decreased or increased levels, respectively, of mRNA expression relative to normal (non-cirrhotic, uninfected) tissue. HCV-infected samples are highlighted in blue.