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Table 5 T-cell responses for subjects grouped by rate of recurrences. Data is the same as Table 2 but subjects have been organized into groups based on the rate of recurrent disease. For CD4 responses, the total of the number of ELISPOTs (E#) for each peptide pool is included. Total number of CD4 ELISPOTs for each protein from each group were used to generate a ratio of the ELISPOTs measured in low recurrence subjects compared to high recurrence subjects. Values were adjusted to compensate for the different number of subjects per group. A second calculation was done in which three subjects (7, 10, 17) that were single positive for HSV-1 were removed.

From: Characterization of the IFN-γ T-cell responses to immediate early antigens in humans with genital herpes

HIGH RECURRENCES PER YEAR (>2)
CD4 Responses CD8 Responses
Subject ICP27 ICP22 ICP0–1 ICP0–2 ICP0–3 ICP4–1 ICP4–2 ICP4–3 ICP4–4 ICP4–5 ICP4–6 VP22 gD   ICP0 ICP4 VP22
1 S S       W W W W S W     
3 W    S      S S S S S    P  
5 W W    S     W     S   P   P
6 W W   S   W W   W    S S     
8   W S      W   W   W W   P   
12   S S   W   W W W S   S S     
14              S     P
15   W S      W   W W S S     P
E# 80 102 121 80 49 9 13 61 112 118 56 374 475     
LOW RECURRENCES PER YEAR (≤2)
CD4 Responses CD8 Responses
Subject ICP27 ICP22 ICP0–1 ICP0–2 ICP0–3 ICP4–1 ICP4–2 ICP4–3 ICP4–4 ICP4–5 ICP4–6 VP22 gD   ICP0 ICP4 VP22
2    W      S   S   W S     P
7         S   W        
9 W    S   W   S   S   W W   P P  
10      W      S        
11 W W      W W     S S     
13      S        S S     
16    W      S     W S     
17         S   S        
18   W   S    W W S   S S W    P  
E# 21 30 45 78 75 5 14 354 46 190 31 196 187     
  ICP27 ICP22 ICP0 ICP4 VP22 gD            
  0.23 0.26 0.70 1.54 0.47 0.35 Low/high recurrence ratio including HSV-1 single positives
  0.35 0.39 1.02 1.49 0.69 0.52 Low/high recurrence ratio without HSV-1 single positives