Table 5 T-cell responses for subjects grouped by rate of recurrences. Data is the same as Table 2 but subjects have been organized into groups based on the rate of recurrent disease. For CD4 responses, the total of the number of ELISPOTs (E#) for each peptide pool is included. Total number of CD4 ELISPOTs for each protein from each group were used to generate a ratio of the ELISPOTs measured in low recurrence subjects compared to high recurrence subjects. Values were adjusted to compensate for the different number of subjects per group. A second calculation was done in which three subjects (7, 10, 17) that were single positive for HSV-1 were removed.

1

S

S

W

W

W

W

S

W

3

W

S

S

S

S

S

S

P

5

W

W

S

W

S

P

P

6

W

W

S

W

W

W

S

S

8

W

S

W

W

W

W

P

12

S

S

W

W

W

W

S

S

S

14

S

P

15

W

S

W

W

W

S

S

P

E#

80

102

121

80

49

9

13

61

112

118

56

374

475

LOW RECURRENCES PER YEAR (≤2)

CD4 Responses

CD8 Responses

Subject

ICP27

ICP22

ICP0–1

ICP0–2

ICP0–3

ICP4–1

ICP4–2

ICP4–3

ICP4–4

ICP4–5

ICP4–6

VP22

gD

ICP0

ICP4

VP22

2

W

S

S

W

S

P

7

S

W

9

W

S

W

S

S

W

W

P

P

10

W

S

11

W

W

W

W

S

S

13

S

S

S

16

W

S

W

S

17

S

S

18

W

S

W

W

S

S

S

W

P

E#

21

30

45

78

75

5

14

354

46

190

31

196

187

ICP27

ICP22

ICP0

ICP4

VP22

gD

0.23

0.26

0.70

1.54

0.47

0.35

0.35

0.39

1.02

1.49

0.69

0.52