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Table 3 Subcellular localization prediction of cytomegalovirus proteins

From: Predicting the subcellular localization of viral proteins within a mammalian host cell

Gene SwissProt Accession PSLT predictionsa Literature annotations Localization References Closest human homologueb BLAST e-value
gp34 P16809 PM PM [6] - > 0.1
UL111A P17150 Secreted Secreted [36] interleukin 10 (NP_000563) 2E-9
UL114 P16769 Nuclear Nuclear [66] uracil-DNA glycosylase (NP_550433) 5E-39
UL118/119 P16739 PM PM [6] - > 0.1
UL18 P08560 PM/secreted PM [67] MHC class Ib antigen (NP_005507) 4E-16
UL33 P16849 PM PM, endosomes, secretory pathway, perinuclear [34,68] chemokine receptor 1 (NP_001286) 3E-21
UL48 P16785 Cytosolic and ER ER, cytosolic, vacuolar [69,70] spen homolog, transcriptional regulator (NP_055816) 0.082
UL54 P08546 Nuclear Nuclear [71] polymerase delta 1 (NP_002682) 3E-50
UL78 P16751 PM PM [34] somatostatin receptor 3 (NP_001042) 0.006
UL97 P16788 PM, cytosolic Golgi, nuclear and cytosolic [72] - > 0.1
US10 P09728 PM ER [33] - > 0.1
US11 P09727 PM ER [4] - > 0.1
US2 P09713 PM ER and cytosolic [5] - > 0.1
US27 P09703 PM PM, endosomes, secretory pathway, perinuclear [34,68] chemokine receptor 1 (NP_001328) 7E-31
US28 P69332 PM PM, endosomes [34,68] chemokine receptor 1 (NP_001328) 2E-55
US3 P09712 PM ER [73,74] - > 0.1
US6 P14334 PM ER [75] - > 0.1
US7 P09731 PM ER [33] - > 0.1
US8 P09730 PM Golgi [33] - > 0.1
US9 P09729 Secreted ER [33] - > 0.1
  1. a In the case of multi-compartmental proteins (proteins that are predicted with high probability to be present in more than one compartment), the two most likely compartments were retained by PSLT. PM: plasma membrane; ER: endoplasmic reticulum.
  2. b The closest human homologue was determined by using BLAST [38] against the NCBI human RefSeq dataset. We do not report a homologue when the BLAST e-value exceeds 0.1.