Genetic variability of the envelope gene of Type D simian retrovirus-2 (SRV-2) subtypes associated with SAIDS-related retroperitoneal fibromatosis in different macaque species

Philipp-Staheli, Jeannette; Marquardt, Taya; Thouless, Margaret E; Bruce, A Gregory; Grant, Richard F; Tsai, Che-Chung; Rose, Timothy M

doi:10.1186/1743-422X-3-11

Virology Journal

Table 1 Macaque sources of SRV-2 isolates

From: Genetic variability of the envelope gene of Type D simian retrovirus-2 (SRV-2) subtypes associated with SAIDS-related retroperitoneal fibromatosis in different macaque species

SRV Serogroup/Subtype	Animal/Virus Isolate	Species¹	Origin²	RF³	Sample	Date⁴	Comments
SRV-1	RM 18610/ D1/RHE/CA	Mmu	CA/cb	-	Tissue homegenate/ in vivo passage	1983	[Genbank:M11841] [6]
SRV-3	D3/RHE/WI	Mmu	WI	-	Breast tumor	1970	Mason-Pfizer monkey virus (MPMV) [Genbank:M12349] [2]
SRV-2A	D2/CEL/OR	Mni	OR	+	PBMC/Raji culture	1985	[Genbank:M16605] [14]
-2A	Mm_Mich	Mmu	MI	-	Spleen	1997
-2A	NM101	Mfa	NM/cb	+	Tongue	2004
SRV-2B	D2/RHE/ORV1	Mmu	OR	-	PBMC/Raji culture	1989	[Genbank:AF126468] [15] → severe SAIDS in rhesus
-2B	D2/RHE/OR	Mmu	OR	-	PBMC/Raji culture	1986	[Genbank:AF126467] [16] → mild SAIDS in rhesus
-2B	YN91-224	Mmu	Yerkes/cb	+	RF tumor	1991	Experimentally infected with SIV in 1989
-2B	90167	Mne	WA/tr	+	RF tumor	1995
-2B	T82422	Mne	WA/cb	+	RF tumor	1984	Diagnosed with RF/SF⁵
-2B	M78114	Mne	WA/cb	+	RF/SF tumor	1984	Diagnosed with RF/SF [68]
-2B	D2/MNE/WA	Mne	WA/cb	+	RF tumor	1982	[17]
SRV-2C	442N	Mne	NIH/tr	+	RF tumor	1996	Experimentally infected with SHIV in 1996 [24]
-2C	17915	Mne	NIH/tr	-	PBMC	1996
-2C	91048	Mfa	WA/tr	-	PBMC	1997
SRV-2D	F90346	Mne	WA/cb	-	PBMC	1992	Same parents as F91249
-2D	F89336	Mne	WA/cb	-	PBMC/A549 culture	1994	Same father as F91249 and F90346
-2D	F91249	Mne	WA/cb	-	PBMC/A549 culture	1991	Same parents as F90346
SRV -2E	A94040	Mfa	WA/tr	-	PBMC	1997	Transferred to WA in 1994, SRV-2 positive, mother of M96026
-2E	M95332	Mfa	WA/cb	-	PBMC Spleen	1997 2003
-2E	M95348	Mfa	WA/cb	-	PBMC	2003	Same father as M96020 and M96026
-2E	M96020	Mfa	WA/cb	-	Tonsils	2003	Same father as M95348 and M96026
-2E	M96026	Mfa	WA/cb	-	PBMC	2003	Child of A94040; same father as M95348 and M96020
SRV-2F	SRV_sing31.2	Mfa	Singapore/wc	-	PBMC	2003	Sampled in wild

¹Species of macaque from which the sample was taken. Mne = Macaca nemestrina; Mmu = Macaca mulatta; Mfa = Macaca fascicularis; Mni = Macaca nigra;
²Primate center origin: WA = Washington NPRC; Yerkes = Yerkes NPRC; OR = Oregon NPRC; NIH = National Institutes of Health, Bethesda MD; MI = University of Michigan; NM = Lovelace Respiratory Research Institute, New Mexico; Singapore = sampled in the wild on the island of Singapore; wc = wild caught; cb = colony born; tr = transferred
³RF = diagnosed with retroperitoneal fibromatosis
⁴Date = approximate date sample obtained
⁵RF/SF = diagnosed with retroperitoneal and subcutaneous fibromatosis

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ISSN: 1743-422X

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