Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genes

Table 1 Clinical symptoms of HCoV-229E infected patients.

			Symptoms
Patient	Age	Year of Sampling	Acute start	Cough	Rhinorrhoea	Sore Throat	Fever	Malaise	Other	Hospitalized	Diagnosis
RIVM 02-034	52	2002	Yes	No	Yes	No	No	Yes	Muscle/joint pain	No	ARI, Pharyngitis
RIVM 02-041	54	2002	Yes	No	Yes	No	Yes	No	Hoarse	No	Common Cold, Acute tonsillitis
RIVM 03-224	68	2003	Yes	No	Yes	Yes	Yes	No	Respiratory allergy	No	Common Cold
RIVM 04-037	54	2004	Yes	Yes	Yes	Yes	Yes	Yes	-	No	ARI
VS03-099*	81	2003	Yes	Yes	U	U	No	Yes	Dyspnoea	Yes	Exacerbation of COPD
CCU-T935^†	U	1986	U	U	U	U	U	U	U	U	U

ISSN: 1743-422X