Figure 1
From: Matrix attachment regions as targets for retroviral integration
Physical map of the MF8T locus. Depicted is the 3.9-kb domain of common proviral insertion designated MF8T. Vertical lines represent the positions of the proviral integrations with the transcriptional orientation of provirus depicted by the direction of the arrow. Depicted is Rasgrp1, the predicted oncogene in the MF8T locus. Two predicted MARs of 0.9-kb and 0.8-kb in size are located 5.1-kb and 3.6-kb from the domain of common insertion. Also depicted are structural motifs typical of MARs, including kinked DNA, curved DNA, AT-rich regions, ORI patterns and Topoisomerase II cleavage site patterns.