Figure 1
From: HBx M130K and V131I (T-A) mutations in HBV genotype F during a follow-up study in chronic carriers
(A) – Persistent chronic hepatitis, Knodell index ≤ 2. Photomicrograph of liver showing chronic hepatitis with minimal activity. Hepatocytes showing regenerative features are seen, with minimal inflammation and scattered ground- glass hepatocytes. Cobblestone arrangement (diffuse regeneration) with Hadziyannis cells and without necrosis or fibrosis. (H&E 250×). (B) – Mild lobular chronic hepatitis, Knodell index 3–4. Photomicrograph of liver showing chronic hepatitis with mild activity. Spotty hepatocyte necrosis is seen in a lobular pattern with focal lymphocytic infiltration. Lesions are characterized by focal necrosis, conserved sinusoidal and trabecular patterns, lobular, portal, and focal lymphocytic infiltrated. (H&E 400×). (C) – Moderate lobular chronic hepatitis, Knodell index > 4. Photomicrograph of liver showing chronic hepatitis with moderate activity. There is portal chronic inflammation, focal interface hepatitis and periportal fibrous septa. Portal chronic swollen periportal apoptosis, post-necrosis fibrous interportal bridges. Nodular regeneration (pre-cirrhosis). (H&E 250×)