Figure 5
From: Macrophages and cytokines in the early defence against herpes simplex virus
Regulation of iNOS induction at the molecular level. Transcription factors controlling induction of the iNOS gene. Activated STAT1 induces transcription of the IRF-1 and iNOS genes, an effect which is competed by activated STAT6. IRF-1 interacts physically with NF-κB, binds to the distal κB-binding site of the iNOS promoter region, and stimulates transcription. Only when NF-κB is absent, IRF-2 can bind to the ISRE site and block transcription. Stimulatory pathways are indicated by green arrows (→), and inhibitory pathways are drawn in red.