Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein

Table 1 Summary of 50% inhibitory concentration values of peptide fusion inhibitors in cell-cell fusion and virus infection assays.

	Virus	Cell line	IC₅₀* Capped NiV FC2 (nM)	IC₅₀ N-PEG NiV FC2 (nM)	IC₅₀ C-PEG NiV FC2 (nM)
Fusion Inhibition	HeV	Vero	17.59	6.54	142.4
	NiV	Vero	13.08	3.66	98.05
	HeV	U373	23.91	9.71	78.07
	NiV	U373	16.28	4.85	79.19
	HeV	PCI 13	27.54	6.18	147.2
	NiV	PCI 13	17.79	5.04	93.32
Live virus Inhibition	HeV	Vero	4.17	0.46	14.28
	NiV	Vero	11.42	1.36	43.76
	HeV	PCI 13	53.51	2.05	11.94
	NiV	PCI 13	2.70	1.26	55.57

*All IC₅₀s were calculated using the non-linear regression function of GraphPad Prism software.

ISSN: 1743-422X