Peptide inhibitors of dengue virus and West Nile virus infectivity

Table 2 Alignment of preanchor domain sequences from representative flaviviruses.

Virus ^a	Pre-anchor sequence ^b	Location ^c
DENV-1	AILGDTAWDFGSIGGVFTSVGKLIHQIFGTA	693–723
DENV-2	AILGDTAWDFGSLGGVFTSIGKALHQVFGAI	693–723
DENV-3	AILGDTAWDFGSVGGVLNSLGKMVHQIFGSA	691–721
DENV-4	AILGETAWDFGSVGGVLTSLGKAVHQVFGSV	692–722
WNV	AVLGDTAWDFGSVGGVFTSVGKAVHQVFGGA	709–739
YFV	AVMGDTAWDFSSAGGFFTSVGKGIHTVFGSA	695–725
SLEV	AVLGDTAWDFGSIGGVFTSIGKALHQVFGGA	707–737
JEV	AALGDTAWDFGSIGGVFNSIGKAVHQVFGGA	712–742
TBEV	TVIGEHAWDFGSAGGFLSSIGKAVHTVLGGA	694–724
OHFV	TVLGEHAWDFGSTGGFLSSIGKALHTVLGGA	694–724
KFV	TVVGEHAWDFGSVGGMLSSVGKALHTAFGAA	695–725
POWV	SVVGEHAWDFGSVGGVLSSVGKAIHTVLGGA	693–723

^aDENV: dengue virus; WNV: West Nile virus; YFV: yellow fever virus; SLEV: St. Louis encephalitis virus; JEV: Japanese encephalitis virus; TBEV: Tick-borne encephalitis virus; OHFV: Omsk hemorrhagic fever virus; KFV: Kyasanur Forest virus; POWV: Powassan virus
^b * = identical or chemically similar amino acids in every sequence
^cnumbering from the beginning of the E polyprotein.