Stereophysicochemical variability plots highlight conserved antigenic areas in Flaviviruses

Table 1 PCP-Motifs identified for the flavivirus Envelope proteins, using the sequence of DV-2env to indicate the sequence location and representative sequence. PCPMer parameters were: Gap cutoff of 2, length cutoff of 5 and the relative entropy range between 1 and 2.5 with a step of 0.1.

*residues 9–12 are at the C-terminal end of the CD8-T-cell epitope mapped for yellow fever [46]
**a Y to H mutation in TBE virus just after this motif is attenuating for neurovirulence [44]
^F Motifs that form the "fusion tip area" of domain II. Mutation of the analogous residue in TBE to the bold and underlined H in motif 13 prevents fusion [32].
ⁱ Residues equivalent to those that form a salt bridge in the TBE-envelope are bold (R9/E368), those in the interface of the trimer of the TBE envelope protein are underlined [31].

ISSN: 1743-422X