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Table 1 PCP-Motifs identified for the flavivirus Envelope proteins, using the sequence of DV-2env to indicate the sequence location and representative sequence. PCPMer parameters were: Gap cutoff of 2, length cutoff of 5 and the relative entropy range between 1 and 2.5 with a step of 0.1.

From: Stereophysicochemical variability plots highlight conserved antigenic areas in Flaviviruses

Motif No. PCP-motifs
1 9 R DF VEGVSG 17*i
2 24 VLEHGSCVTTMAKNKPTLD 42
3 54 ATLRKYCIEA 63
4 74 CPTQGEP 80F
5 98 DRGWGNGCGLFGKGG 112F
6 116 CAMFTC 121
7 133 ENLEYTV 139
8 151 VGNDT 155
9 159 GKEVKIT PQSS 169
10 175 LTGYGTVTMEC 185
11 197 VLLQMK 202
12 209 HRQW FLD 215
13 240 FKNPH AKKQDV 250F
14 281 GHLKCRLRMDKLQLKGMSYSMC 302
15 314 ETQHGT 319
16 332 PCKIPF 337
17 349 GRLI TV NP 356
18 368 E AE PPFGD 375**
19 391 WFKKGSSIGQ 400
20 416 GDTAWDFGSLGG 427
21 431 SIGKALHQVFGAI 443
22 448 FSGVSW 453
23 459 IGVIITWIGMNSR 471
24 475 LSVSLVLVGVVTLYL 489
  1. *residues 9–12 are at the C-terminal end of the CD8-T-cell epitope mapped for yellow fever [46]
  2. **a Y to H mutation in TBE virus just after this motif is attenuating for neurovirulence [44]
  3. F Motifs that form the "fusion tip area" of domain II. Mutation of the analogous residue in TBE to the bold and underlined H in motif 13 prevents fusion [32].
  4. i Residues equivalent to those that form a salt bridge in the TBE-envelope are bold (R9/E368), those in the interface of the trimer of the TBE envelope protein are underlined [31].