Figure 5

The conserved essential residues in two serotype specific T-cell epitopes of the NS3 protease are followed by variable residues that will affect MHC binding. The crystal structure of the NS3 protease of DV-2 is colored according to sequence variability across the flaviviruses(see figure 1 and 2 for details). The catalytic triad sidechains are shown in neon and labeled. The T-cell epitopes (right) around the catalytic residues Asp75 (residues 71–79), and Ser135 (133–143), are shown as space filling and color coded to reflect variability, except that the 100% conserved catalytic residues are both black.