Figure 3
From: Regulation of gene expression by microRNA in HCV infection and HCV–mediated hepatocellular carcinoma
Increased expression of miR-21 and its validated targets. miR-21 expression can be activated by transcription factor AP-1, while miR-21 has negative downstream effects on the targets resulting in different biological outcome. The targets are represented as blue circles, while diamond represents the protein/transcription factor. The red bars represent down-regulation and the green arrows indicate the up-regulation.