Figure 2
From: Regulation of gene expression by microRNA in HCV infection and HCV–mediated hepatocellular carcinoma
Mechanisms by which the cellular miRNA can affect the replication of HCV. Cellular miRNAs may bind the viral mRNAs and thereby promote the viral replication e.g. miR-122, a liver specific miRNA that can promote HCV RNA replication. The cellular miRNAs can bind to the viral genes and limit the HCV RNA replication e.g. miR-199a-3p and miR-196. Finally cellular miRNAs might promote or limit the viral replication by inhibition of the cellular mRNAs.