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Table 4 Univariate analysis of the factors affecting IFN α-2b therapeutic efficacy

From: Correlation between the suppressor of cytokine signaling-1 and 3 and hepatitis B virus: possible roles in the resistance to interferon treatment

  Responders (n = 8) Non-responders (n = 16) χ2/t/U P values
Age (years) (Mean ± SD) 23.75 ± 5.60 25.50 ± 9.45 -0.48 0.64
Gender (Male/Female) 7/1 6/10 0.03
Genotype (A/B/C) 0/6/2 1/3/12 7.29 0.03
HBeAg (+/–) 8/0 16/0
HBeAb (+/–) 0/8 0/16
ALT (IU/L) 251.50 ± 108.03 205.19 ± 94.44 -1.03 0.31
AST (IU/L) 106.63 ± 36.92 107.19 ± 73.09 -0.02 0.98
ALB (g/L) 37.95 ± 1.48 36.49 ± 2.39 1.57 0.13
TBIL (mg/dL) 24.27 ± 13.63 25.62 ± 9.59 -0.28 0.78
CHE (U/L) 6218.50 ± 477.86 6677.25 ± 620.29 -1.83 0.08
CREA (mg/dL) 72.11 ± 62.02 67.49 ± 9.55 0.30 0.77
INR for PT 2.20 ± 0.41 2.02 ± 0.50 0.88 0.39
HBV DNA level 15.34 ± 1.29 18.09 ± 1.32 -4.85 0.001
SOCS-1 5.13 ± 1.89 15.38 ± 3.65 -7.40 0.001
SOCS-3 6.75 ± 1.58 20.63 ± 3.24 -11.37 0.001