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Figure 2 | Virology Journal

Figure 2

From: Circulating human microRNAs are not linked to JC polyomavirus serology or urinary viral load in healthy subjects

Figure 2

Comparison of all miRNAs assessed by RT-qPCR analysis of RNA isolated from plasma of subjects with negative urine JCPyV Viral Load (VL, n = 10) or subjects with positive urine JCPyV Viral Load (VL+, n = 10). A. Volcano plot of pairwise comparisons. The volcano plot displays the relationship between fold-change and significance between the two groups, using a scatter plot view. The y-axis is the negative log10 of P values (a higher value indicates greater significance) and the x-axis is the difference in expression between two experimental groups as measured in log2 space. MiRNAs that were selected for further analysis are indicated in red on the plot. B. Mann-Whitney p-values, adjusted p-values and fold changes (fc) of subjects with positive urine JCPyV Viral Load (VL+) vs. subjects with negative urine JCPyV Viral Load (VL) for miRNAs with p-value < 0.05. C. Relative expression levels of selected circulating miRNAs in subjects from each group. Data is presented relative to the mean of the entire population in log10 scale (n = 30).

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