Table 1 HLA class I predicted epitopes of HCV genotype 5a and their antigenicity prediction score, number of allele and conservation (in percentages) in different genotypes
From: Prediction of T-cell epitopes of hepatitis C virus genotype 5a
Position | Epitope sequence | No of allele | Antigenecity score | Genotype 1a | Genotype 1b | Genotype 2 | Genotype 3 | Genotype 4 | Genotype 6 |
|---|---|---|---|---|---|---|---|---|---|
E2 | Â | ||||||||
651 | RCDLEDRDR | 9 | 2.7428 | Â | Â | Â | Â | Â | Â |
677 | CSFTPTPAL | 27 | 0.8772 | CSFTTLPAL (94) | CSFTTLPAL (92) | Â | CSFTPMPAL (73) | Â | Â |
684 | 29 | 0.9005 | ALSTGLIHL (70) | ALSTGLIHL (99) | ALSTGLIHL (97) | ALSTGLIHL (97) | ALSTGLIHL (84) | ALSTGLIHL (91) | |
NS2 | |||||||||
861 | VPPLQVRGG | 6 | 1.4312 | VPPLNVRGG (85) | Â | Â | Â | Â | Â |
NS3 | Â | ||||||||
1032 | YAQQTRGVL | 26 | 0.7638 | YAQQTRGLL (99) | Â | Â | Â | Â | Â |
1033 | AQQTRGVLG | 5 | 0.7751 | AQQTRGLLG (99) | Â | Â | Â | Â | Â |
1128 | ADLYLVTRH | 5 | 1.0277 | SDLYLVTRH (99) | SDLYLVTRH (99) | VDLYLVTRN (92) | Â | Â | Â |
1325 | TILGIGTVL | 30 | 0.7555 | SILGIGTVL (93) | Â | TILGIGTVL (88) | SILGIGTVL (94) | TILGIGTVL (82) | Â |
1332 | VLDQAETAG | 5 | 0.5004 | VLDQAETAG (96) | VLDQAETAG (98) | VLDQAETAG (96) | VLDQAETAG (100) | VLDQAETAG (93) | VLDQAETAG (71) |
1357 | TPHPNIEEV | 24 | 0.8423 | VPHPNIEEV (89) | VPHPNIEEV (80) | Â | VPHSNIEEV (94) | Â | Â |
1359 | 24 | 1.1654 | HPNIEEVAL (88) | HPNIEEVAL (76) | Â | HSNIEEVAL (94) | Â | Â | |
1370 | EGEIPFYGR | 9 | 1.0560 | TGEIPFYGK (97) | Â | Â | Â | Â | Â |
1374 | PFYGRAIPL | 7 | 0.9479 | PFYGKAIPL (99) | PFYGKAIPI (85) | PFYGKAIPL (82) | Â | Â | PFYGKAIPL (73) |
1642 | TKYIMACMS | 6 | 0.7008 | PFYGKAIPL (99) | TKYIMACMS (70) | Â | TKYIMACMS (70) | TKYIMACMS (93) | TKYIMTCMS (87) |
NS4B | |||||||||
1712 | SASLPYMDE | 5 | 0.5488 | Â | Â | Â | Â | Â | Â |
1819 | QIAPPTAAT | 5 | 0.5293 | QLAAPGAAT (99) | QLAPPSAAS (94) | QIAPPAGAT (91) | Â | QIATPTAST (89) | Â |
1832 | SGMAGAAVG | 5 | 0.8750 | AGLAGAAIG (81) | AGIAGAAVG (93) | SGLVGAAVG (98) | SGLAGAAIG (76) | Â | Â |
1848 | LIDILAGYG | 5 | 0.8431 | LVDILAGYG (94) | LVDILAGYG (95) | Â | LLDILAGYG (79) | LVDILAGYG (84) | Â |
1854 | GYGAGVAGA | 9 | 0.5562 | GYGAGVAGA (99) | GYGAGVAGA (99) | Â | GYGAGVSGA (94) | GYGAGVAGA (91) | GYGAGVSGA (84) |
NS5B | |||||||||
2522 | GYGAKEVRS | 7 | 1.3540 | GYGAKDVRC (95) | GYGAKDVRN (84) | GFGAKEVRS (93) | GYSAKDVRS (79) | Â | Â |
2557 | TIMAKNEVF#[32] | 12 | 0.6303 | TIMAKNEVF (99) | TIMAKNEVF (80) | TIMAKNEVF (83) | TIMAKNEVF (100) | TIMAKNEVF (84) | TIMAKNEVF (93) |
2568 | EPSKGGKKP | 6 | 1.4218 | QPEKGGRKP (93) | Â | Â | Â | Â | Â |
2720 | LASCRAAKL | 28 | 0.5264 | Â | Â | Â | Â | Â | Â |
2886 | LHGLSAFSL | 11 | 0.6732 | LHGLSAFSL (99) | LHGLSAFSL (98) | Â | Â | LHGLSAFTL(82) | LHGMAAFSL (98) |