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Figure 3 | Virology Journal

Figure 3

From: Emerging antiviral resistant strains of influenza A and the potential therapeutic targets within the viral ribonucleoprotein (vRNP) complex

Figure 3

PA-PB1 interaction site is an antiviral target. Analysis of the PAC-PB1N crystal structure “3CM8” [68] using Deep View-Swiss-PdbViewer 4.0. Residues 1–16 of PB1 (red) are shown in interaction with residues 258–716 of PA (blue). Many small molecule inhibitors of PA resemble the N terminus of PB1 and bind in the hydrophobic pocket blocking essential interactions between the polymerase subunits [68, 73, 95].

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Virology Journal

ISSN: 1743-422X