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Table 1 Replication of recombinant RSV in the upper and lower respiratory tract of BALB/c mice

From: Development of a reverse genetics system for respiratory syncytial virus long strain and an immunogenicity study of the recombinant virus

Days collectedb Virusa Lung Nose
Mean titer ± SDc Mean titer ± SDc
   (log10PFU g−1) (log10PFU ml−1)
3 RSV-Long 4.52 ± 0.29 3.62 ± 0.52
rLong 3.20 ± 0.18 2.50 ± 0.12
rLong-∆G-EGFP 2.76 ± 0.36 <1.98
5 RSV-Long 4.42 ± 0.60 3.48 ± 0.25
rLong 2.86 ± 0.32 2.05 ± 0.08
rLong-∆G-EGFP <2.68 <1.98
7 RSV-Long 2.95 ± 0.224 2.65 ± 0.15
rLong <2.68 <1.98
  rLong-∆G-EGFP <2.68 <1.98
  1. aBALB/c mice were inoculated with 105 PFU of (recombinant) virus. bLungs and nasal washes were collected, and virus titers were determined on the indicated day: 3, 5, or 7. cThe lower limits of detection for virus in the lungs and nose were 2.68 log10 PFU g−1 and 1.98 log10 PFU ml−1, respectively. Each group consisted of six animals.