Comparison of multiple DNA vaccines for protection against cytomegalovirus infection in BALB/c mice

Table 1 Survival rates of mice after lethal virus challenge ^§

Vaccine	Survival rates (No. of survivors/No. tested)
Vaccine	One dose	Two doses	Three doses	Four doses
M04	13/16 (81.3%)^a,b	15/16 (93.8%)^a,b	16/16 (100%)^a,b	16/16 (100%)^a,b
M84	12/16 (75%)^a,b	16/16 (100%)^a,b	16/16 (100%)^a,b	16/16 (100%)^a,b
M105	5/16 (31.3%)^a	6/16 (37.5%)^a	8/16 (50%)^a	10/16 (62.5%)^a
IE-1	11/16 (68.8%)^a,b	14/16 (87.5%)^a,b	16/16 (100%)^a,b	16/16 (100%)^a,b
M55	0/16 (0%)	0/16 (0%)	9/16 (56.3%)^a	10/16 (62.5%)^a
Control	0/16(0%)

^§Mice were immunized 1 ~ 4 times, at an interval of 2 weeks, with 100 μg plasmid DNAs. Two weeks after the final immunization, mice were challenged with a lethal dose (3 × LD50) of SG-MCMV. The survival rates of mice were determined 21 days postinfection.
^aSignificant difference compared with control animals, P < 0.05.
^bSignificant difference compared with the M55 group at the same immunization frequency.

ISSN: 1743-422X