Transcriptional analysis of the innate immune response of ducks to different species-of-origin low pathogenic H7 avian influenza viruses

Table 2 Functional gene ontology annotation using DAVID

Gene name	KEGG pathway
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	gga00190:Oxidative phosphorylation, gga04142:Lysosome
F-box protein 4	gga04120:Ubiquitin mediated proteolysis
cadherin 1, type 1, E-cadherin (epithelial)	gga04514:Cell adhesion molecules (CAMs), gga04520:Adherens junction
erbb2 interacting protein	gga04621:NOD-like receptor signaling pathway
etoposide induced 2.4 mRNA	gga04115:p53 signaling pathway
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	gga04060:Cytokine-cytokine receptor interaction, gga04620:Toll-like receptor signaling pathway, gga04622:RIG-I-like receptor signaling pathway, gga04630:Jak-STAT signaling pathway
jun oncogene	gga04010:MAPK signaling pathway, gga04012:ErbB signaling pathway, gga04310:Wnt signaling pathway, gga04510:Focal adhesion, gga04620:Toll-like receptor signaling pathway, gga04912:GnRH signaling pathway
mago-nashi homolog, proliferation-associated (Drosophila)	gga03040:Spliceosome
phosphomannomutase 2	gga00051:Fructose and mannose metabolism, gga00520:Amino sugar and nucleotide sugar metabolism
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)	gga03050:Proteasome
ribosomal protein L35a	gga03010:Ribosome
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)	gga04510:Focal adhesion, gga04512:ECM-receptor interaction, gga04620:Toll-like receptor signaling pathway
thioredoxin reductase 1	gga00240:Pyrimidine metabolism

The gene list containing the 61 differentially expressed genes in duck spleen common to all three LPAIV infections at 3 d.p.i. was entered into the DAVID functional annotation software. The following genes and their cognate KEGG pathways are enriched (up- and/or down-regulated) in our dataset.

ISSN: 1743-422X