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Table 2 Functional gene ontology annotation using DAVID

From: Transcriptional analysis of the innate immune response of ducks to different species-of-origin low pathogenic H7 avian influenza viruses

Gene name

KEGG pathway

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

gga00190:Oxidative phosphorylation, gga04142:Lysosome

F-box protein 4

gga04120:Ubiquitin mediated proteolysis

cadherin 1, type 1, E-cadherin (epithelial)

gga04514:Cell adhesion molecules (CAMs), gga04520:Adherens junction

erbb2 interacting protein

gga04621:NOD-like receptor signaling pathway

etoposide induced 2.4 mRNA

gga04115:p53 signaling pathway

interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

gga04060:Cytokine-cytokine receptor interaction, gga04620:Toll-like receptor signaling pathway, gga04622:RIG-I-like receptor signaling pathway, gga04630:Jak-STAT signaling pathway

jun oncogene

gga04010:MAPK signaling pathway, gga04012:ErbB signaling pathway, gga04310:Wnt signaling pathway, gga04510:Focal adhesion, gga04620:Toll-like receptor signaling pathway, gga04912:GnRH signaling pathway

mago-nashi homolog, proliferation-associated (Drosophila)

gga03040:Spliceosome

phosphomannomutase 2

gga00051:Fructose and mannose metabolism, gga00520:Amino sugar and nucleotide sugar metabolism

proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)

gga03050:Proteasome

ribosomal protein L35a

gga03010:Ribosome

secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)

gga04510:Focal adhesion, gga04512:ECM-receptor interaction, gga04620:Toll-like receptor signaling pathway

thioredoxin reductase 1

gga00240:Pyrimidine metabolism

  1. The gene list containing the 61 differentially expressed genes in duck spleen common to all three LPAIV infections at 3 d.p.i. was entered into the DAVID functional annotation software. The following genes and their cognate KEGG pathways are enriched (up- and/or down-regulated) in our dataset.