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Table 3 Results of determination on HBV DNA in serum and tissue samples

From: Histopathological changes in the liver of tree shrew (Tupaia belangeri chinensis) persistently infected with hepatitis B virus

Group

Experimental no.

HBV DNA in serum (Copies/ml)a

HBV DNA in liver

Copies/μg liver DNAb

Copiesc

P-value

A (n = 6)

A1

2.63 × 106

1.83 × 108

1.12 ± 0.99 × 108

 

A2

5.22 × 103

1.27 × 108

  

A3

8.74 × 106

5.17 × 108

  

A4

1.09 × 106

2.64 × 108

  

A5*

-

7.61 × 104

  

A6

2.42 × 105

4.36 × 107

  

B (n = 3)

B1

-

9.58 × 105

3.56 ± 5.22 × 105

0.039d

    

0.400b

B2

-

3.91 × 104

 

0.400e

B3

-

7.04 × 104

  

C (n = 4)

C1

-

6.35 × 104

5.06 ± 2.18 × 104

0.011d

C2

-

1.90 × 104

  

C3

-

6.63 × 104

  

C4

-

5.34 × 104

  
  1. aHBV DNA copy number ≥103 in serum is defined as a positive; bHBV DNA copy number ≥105 in liver tissue is defined as a positive; cResults are shown as mean ± SD; dCompared with group A; eCompared with group C.
  2. *: This animal had showed 1.1 × 107 copies/ml in serum, 3.73 × 105 and 1.82 × 108 copies/μg in liver at the time points of 60- and 72-Weeks after inoculation.
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Virology Journal

ISSN: 1743-422X