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Figure 1 | Virology Journal

Figure 1

From: Combination of autophagy inducer rapamycin and oncolytic adenovirus improves antitumor effect in cancer cells

Figure 1

Structure of the Ads. The wild-type Ad (Adwt) with the E1a and E1b genes and their endogenous promoters is shown at the top. The left inverted terminal repeat (ITR), the promoters for E1a gene and E1b genes (E1a-P and E1b-P) and the E1a and E1b open reading frames are indicated. The solid lines represent Adwt regions in these viruses, and the dashed lines represent the deleted regions. AdGFP contains the complete deletion of E1a and E1b regions and their promoters. Ad-cycE contains the deletion of E1b region and a cyclin E promoter (cycE-P) was inserted to replace the deleted E1a promoter.

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Virology Journal

ISSN: 1743-422X